If your miner fails to connect and shows error 10061, probably the pool is down.
This happened recently to the main 50btc.com pool. To resolve the issue, pick another one, like pool-ru and connect to it. By the way, guiminer stores settings in your roaming profile,
c:\Users\Username\AppData\Roaming\poclbm\poclbm.ini
so don’t forget to move this file when copying your setup to another machine.